Princeton researchers find a path toward Hep E treatment by disentangling its knotty structure

Written by
Caitlin Sedwick for the Department of Molecular Biology
Feb. 28, 2023

The hepatitis E virus protein ORF1 contains a region that scientists have struggled to characterize, making the structure and function of this region the subject of much debate. Now, Princeton scientists show that this region of the protein does not behave as a protease, as has been previously suggested, but instead serves as a molecular scaffold to stabilize the rest of the ORF1 protein.